To kill or not to kill, that is the question: cytocidal antimalarial drug resistance

To kill or not to kill, that is the question: cytocidal antimalarial drug resistance.

Elucidating mechanisms of antimalarial drug resistance accelerates development of improved diagnostics and the design of new, effective malaria therapy. Recently, several studies have emphasized that chloroquine (CQ) resistance (CQR) can be quantified in two very distinct ways, depending on whether sensitivity to the growth inhibitory effects or parasite-kill effects of the drug are being measu...

DNA vaccines and apoptosis: to kill or not to kill?

The Journal of Clinical Investigation | July 2003 | Volume 112 | Number 1 RNase. Proc. Natl. Acad. Sci. U. S. A. 100:4102-4107. 14. Shinkura, R., et al. 2003. The influence of transcriptional orientation on endogenous switch region function. Nat. Immunol. 4:435–441. 15. Yu, K., Chedin, F., Hsieh, C.L., Wilson, T.E., and Lieber, M.R. 2003. R-loops at immunoglobulin class switch regions in the ch...

Do genes allow inflammation to kill or not to kill?

coeliac disease: to classify or not to classify – that is the question!

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To kill or not to kill: the eradication of contagious bovine pleuro-pneumonia in western Europe.

The use of slaughter or "stamping-out" programmes has been a consistent feature of public animal health strategies, in Western Europe at least, for some three centuries to the present date. Originally developed in the early eighteenth century, the concept survived the explosion of veterinary scientific knowledge and capacity from the late nineteenth century onwards. Its importance has been main...